Paediatric Hematology Oncology is a super-specialty division of the department of Medical Oncology. It deals with all the blood related diseases in children, like anemia (low haemoglobin), thrombocytopenia (low platelets), coagulopathy (bleeding disorders including haemophilia). It also includes all types of blood cancers including lymphomas and leukemia.
Benign hematological disorders | Malignant hematology |
Anemia | Anemia Acute lymphoblastic leukemia |
Platelet related disorders (Immune thrombocytopenia, ITP) | Acute myeloid leukemia |
Thalassemia | Chronic myeloid leukemia |
Sickle cell anemia | Hodgkin Lymphoma |
Aplastic anemia | Non Hodgkin Lymphoma |
Inherited bone marrow failure syndromes (Fanconi anemia) | Myelodysplastic syndrome |
Autoimmune hemolytic anemia | |
Hemophilia | Myeloproliferative neoplasm |
Von Willebrand disease | Langerhans cell histiocytosis (LCH) |
Thrombotic disorders | Hemophagocytic lymphohistiocytosis (HLH) |
Herediatry spherocytosis | |
Congenital dyserythropoetic anemia | |
Hemophagocytic lymphohistiocytosis (HLH) |
Bone marrow transplant (Stem cell transplant) is a specialized therapy done for benign as well as malignant disorders in which the faulty bone marrow of the patient is replaced by healthy stem cells from bone marrow/peripheral blood of the donor. This procedure involves transplanting blood stem cells, which travel to the bone marrow where they produce new blood cells and promote growth of new marrow. It is the curative modality for many diseases. Bone marrow transplant is very skilled and complicated procedure which is available at very few centres in India.
The bone marrow transplant is indicated for the following conditions:
Benign disorders | Malignant disorders |
Thalassemia | High risk acute lymphoblastic leukemia (Eg. Ph positive ALL) |
Sickle cell anemia | Acute myeloid leukemia |
Aplastic anemia | Refractory and relapsed lymphoma |
Inherited bone marrow failure syndromes | Relapsed/ Refractory leukemia |
Primary immunodeficiency disorders | Relapsed or high risk paediatric solid tumors |
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